Lilly drug chosen for Alzheimer's prevention study

Researchers have chosen an experimental drug by Eli Lilly & Co. for a large federally funded study testing whether it's possible to prevent Alzheimer's disease in older people at high risk of developing it.

The drug, called solanezumab (sol-ah-NAYZ-uh-mab), is designed to bind to and help clear the sticky deposits that clog patients' brains.

Earlier studies found it did not help people with moderate to severe Alzheimer's but it showed some promise against milder disease. Researchers think it might work better if given before symptoms start.

"The hope is we can catch people before they decline," which can come 10 years or more after plaques first show up in the brain, said Dr. Reisa Sperling, director of the Alzheimer's center at Brigham and Women's Hospital in Boston.

She will help lead the new study, which will involve 1,000 people ages 70 to 85 whose brain scans show plaque buildup but who do not yet have any symptoms of dementia. They will get monthly infusions of solanezumab or a dummy drug for three years. The main goal will be slowing the rate of cognitive decline. The study will be done at 50 sites in the U.S. and possibly more in Canada, Australia and Europe, Sperling said.

In October, researchers said combined results from two studies of solanezumab suggested it might modestly slow mental decline, especially in patients with mild disease. Taken separately, the studies missed their main goals of significantly slowing the mind-robbing disease or improving activities of daily living.

Those results were not considered good enough to win the drug approval. So in December, Lilly said it would start another large study of it this year to try to confirm the hopeful results seen patients with mild disease. That is separate from the federal study Sperling will head.

About 35 million people worldwide have dementia, and Alzheimer's is the most common type. In the U.S., about 5 million have Alzheimer's. Current medicines such as Aricept and Namenda just temporarily ease symptoms. There is no known cure.

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Online:

Alzheimer's info: http://www.alzheimers.gov

Alzheimer's Association: http://www.alz.org

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Wall Street Week Ahead: Earnings, money flows to push stocks higher

NEW YORK (Reuters) - With earnings momentum on the rise, the S&P 500 seems to have few hurdles ahead as it continues to power higher, its all-time high a not-so-distant goal.

The U.S. equity benchmark closed the week at a fresh five-year high on strong housing and labor market data and a string of earnings that beat lowered expectations.

Sector indexes in transportation <.djt>, banks <.bkx> and housing <.hgx> this week hit historic or multiyear highs as well.

Michael Yoshikami, chief executive at Destination Wealth Management in Walnut Creek, California, said the key earnings to watch for next week will come from cyclical companies. United Technologies reports on Wednesday while Honeywell is due to report Friday.

"Those kind of numbers will tell you the trajectory the economy is taking," Yoshikami said.

Major technology companies also report next week, but the bar for the sector has been lowered even further.

Chipmakers like Advanced Micro Devices , which is due Tuesday, are expected to underperform as PC sales shrink. AMD shares fell more than 10 percent Friday after disappointing results from its larger competitor, Intel . Still, a chipmaker sector index <.sox> posted its highest weekly close since last April.

Following a recent underperformance, an upside surprise from Apple on Wednesday could trigger a return to the stock from many investors who had abandoned ship.

Other major companies reporting next week include Google , IBM , Johnson & Johnson and DuPont on Tuesday, Microsoft and 3M on Thursday and Procter & Gamble on Friday.

CASH POURING IN, HOUSING DATA COULD HELP

Perhaps the strongest support for equities will come from the flow of cash from fixed income funds to stocks.

The recent piling into stock funds -- $11.3 billion in the past two weeks, the most since 2000 -- indicates a riskier approach to investing from retail investors looking for yield.

"From a yield perspective, a lot of stocks still yield a great deal of money and so it is very easy to see why money is pouring into the stock market," said Stephen Massocca, managing director at Wedbush Morgan in San Francisco.

"You are just not going to see people put a lot of money to work in a 10-year Treasury that yields 1.8 percent."

Housing stocks <.hgx>, already at a 5-1/2 year high, could get a further bump next week as investors eye data expected to support the market's perception that housing is the sluggish U.S. economy's bright spot.

Home resales are expected to have risen 0.6 percent in December, data is expected to show on Tuesday. Pending home sales contracts, which lead actual sales by a month or two, hit a 2-1/2 year high in November.

The new home sales report on Friday is expected to show a 2.1 percent increase.

The federal debt ceiling negotiations, a nagging worry for investors, seemed to be stuck on the back burner after House Republicans signaled they might support a short-term extension.

Equity markets, which tumbled in 2011 after the last round of talks pushed the United States close to a default, seem not to care much this time around.

The CBOE volatility index <.vix>, a gauge of market anxiety, closed Friday at its lowest since April 2007.

"I think the market is getting somewhat desensitized from political drama given, this seems to be happening over and over," said Destination Wealth Management's Yoshikami.

"It's something to keep in mind, but I don't think it's what you want to base your investing decisions on."

(Reporting by Rodrigo Campos, additional reporting by Chuck Mikolajczak and Caroline Valetkevitch; Editing by Kenneth Barry)

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The Lede Blog: Bulgarian Politician Faces Off With Gunman During Televised Conference

A man climbed onstage and attempted to fire a gas pistol Saturday at the leader of the country’s ethnic Turkish political party while he was giving a speech at his party’s annual conference in Sofia, the capital of Bulgaria.

The gun misfired, according to a BBC report citing Bulgarian officials, and Ahmed Dogan, the leader of the Movement for Rights and Freedoms, was not harmed. Video of the incident shows Mr. Dogan pushing the gunman’s hand, then diving away as other people at the conference wrestle the man to the floor, then punch and kick him repeatedly. The gun, a small gas pistol, lies nearby at the feet of shocked onlookers.

“A gas pistol is a nonlethal weapon used for self-defense,” The Associated Press reported, “but experts say when fired from close range it can cause life-threatening injuries.”

The gunman was arrested, the news agency said, identifying him as “25-year-old Oktai Enimehmedov, a Bulgarian national and ethnic Turk, from the coastal city of Burgas.” The motive for the attack was not immediately clear. The report said the assailant was also carrying two knives.

Mr. Dogan’s party represents ethnic Turks and other Muslims, according to Reuters, who make up “12 percent of Bulgaria’s 7.3 million-strong population.”

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Nintendo’s Wii U problems turn into a crisis

In just a week, the problems Nintendo’s (NTDOY) new home console is facing have cascaded into something sinister. The traditional post-New Year slump hit Nintendo’s home market in the week ending January 12 and exposed cruelly how weak the consumer interest in Wii U truly is. According to Famitsu, Wii U sales slumped from a pace of 70,000 per week to just 21,000. The ancient PlayStation 3 sold the exact same number of units, which is nothing short of a debacle for Nintendo. The hot portable console 3DS saw its sales slow down from 305,000 units to 106,000 units.  This means that Nintendo’s portable machine is now outselling the brand new home console by a 5-to-1 margin in Japan.

[More from BGR: BlackBerry 10 browser smokes iOS 6 and Windows Phone 8 in comparison test [video]]

No matter how weak the Wii U sales are now, they are likely to get worse. The launch dates of key games seem to be slipping from March quarter to June quarter, including the important Pikmin, Wario and Wii Fit franchises. The Wii U now must depend on Rayman and Lego City in coming months.

[More from BGR: Paid apps are history]

This is a scary prospect, because it now seems that Sony (SNE) is planning to unveil the PlayStation 4 in May and Microsoft (MSFT) is expected to announce the Xbox 720 in June. Nintendo rushed its console out in late 2012 to get a running start before the big guns of the home console industry grab the consumer interest with their new machines. That gambit may now be about to backfire in a spectacular manner. As demand for Wii U is already fizzling in Japan and key games slip from the first quarter of 2013, Wii U faces a very hard January-March period. Sony and Microsoft are then inevitably going to start leaking information about their new consoles in April-May time frame in the run-up to their big unveilings in the second half of the spring quarter.

The clock is ticking for Wii U. If consumers start smelling the scent of the grave emanating from the console just when Sony and Microsoft roll out their new gear, Wii U could face a sudden rejection in the market place by early summer. Nintendo needs some big new titles to revive its home machine very soon.

This article was originally published on BGR.com

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The Wanted's Nathan Sykes Sends Sad Message About His Dog

People Pets

01/19/2013 at 02:10 PM EST

The message, short and sweet, says it all.

"R.I.P Harry dog," Tweeted Nathan Sykes, of the English-Irish boy band The Wanted, along with a pic of himself with the photogenic prized pooch.

"Thanks for all of the memories, smiles and love. We're gonna miss you," said the 19-year-old musician.

Fans clearly responded appropriately. An hour after Sykes's original post went up on Saturday, he Tweeted again.

"Thanks for all of your lovely tweets :)," he said, "making me smile."

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Flu season 'bad one for the elderly,' CDC says

The number of older people hospitalized with the flu has risen sharply, prompting federal officials to take unusual steps to make more flu medicines available and to urge wider use of them as soon as symptoms appear.

The U.S. is about halfway through this flu season, and "it's shaping up to be a worse-than-average season" and a bad one for the elderly, said Dr. Thomas Frieden, director of the Centers for Disease Control and Prevention.

It's not too late to get a flu shot, and "if you have symptoms, please stay home from work, keep your children home from school" and don't spread the virus, he said.

New figures from the CDC show widespread flu activity in all states but Tennessee and Hawaii. Some parts of the country are seeing an increase in flu activity "while overall activity is beginning to go down," Frieden said. Flu activity is high in 30 states and New York City, up from 24 the previous week.

Nine more children or teens have died of the flu, bringing the nation's total this flu season to 29. That's close to the 34 pediatric deaths reported during all of the last flu season, although that one was unusually light. In a typical season, about 100 children die of the flu and officials said there is no way to know whether deaths this season will be higher or lower than usual.

The government doesn't keep a running tally of adult deaths from the flu, but estimates that it kills about 24,000 people most years.

So far, half of confirmed flu cases are in people 65 and older. Lab-confirmed flu hospitalizations totaled 19 for every 100,000 in the population, but 82 per 100,000 among those 65 and older, "which is really quite a high rate," Frieden said.

"We expect to see both the number and the rates of both hospitalizations and deaths rise further in the next week or so as the flu epidemic progresses,'" so prompt treatment is key to preventing deaths, he said.

About 90 percent of flu deaths are in the elderly; the very young and people with other health problems such as diabetes are also at higher risk.

If you're worried about how sick you are and are in one of these risk groups, see a doctor, Frieden urged. One third to one half of people are not getting prompt treatment with antiviral medicines, he said.

Two drugs — Tamiflu and Relenza — can cut the severity and risk of death from the flu but must be started within 48 hours of first symptoms to do much good. Tamiflu is available in a liquid form for use in children under 1, and pharmacists can reformulate capsules into a liquid if supplies are short in an area, said Dr. Margaret Hamburg, head of the Food and Drug Administration.

To help avoid a shortage, the FDA is letting Tamiflu's maker, Genentech, distribute 2 million additional doses of capsules that have an older version of package insert.

"It is fully approved, it is not outdated," just lacks information for pharmacists on how to mix it into a liquid if needed for young children, she said.

This year's flu season started about a month earlier than normal and the dominant flu strain is one that tends to make people sicker. Vaccinations are recommended for anyone 6 months or older. There's still plenty of vaccine — an update shows that 145 million doses have been produced, "twice the supply that was available only several years ago," Hamburg said.

About 129 million doses have been distributed already, and a million doses are given each day, Frieden said. The vaccine is not perfect but "it's by far the best tool we have to prevent influenza," he said.

Carlos Maisonet, 73, got a flu shot this week at New York's Brooklyn Hospital Center at the urging of his wife, who was vaccinated in August.

"This is his first time getting the flu shot," said his wife, Zulma Ramos.

Last week, the CDC said the flu again surpassed an "epidemic" threshold, based on monitoring of deaths from flu and a frequent complication, pneumonia. The flu epidemic happens every year and officials say this year's vaccine is a good match for strains that are going around.

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Online:

Flu vaccine finder: http://www.flu.gov

CDC flu info: http://www.cdc.gov/flu/index.htm

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AP Photographer Bebeto Matthews in New York contributed to this report.

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Wall Street slips after disappointing Intel results

NEW YORK (Reuters) - Stocks edged lower on Friday from a five-year high for the S&P 500 as a weak outlook from tech heavyweight Intel offset a better-than-expected quarterly profit at Morgan Stanley.

But the S&P 500 was still on track to end higher for a third consecutive week.

Shares of Intel Corp slumped nearly 7 percent to $21.11 a day after it forecast quarterly revenue below analysts' estimates and announced plans for increased capital spending amid slow demand for personal computers.

"Intel earnings weren't that bad, although their revenue was weak. It sparks fears about not only the company but about the whole PC sector, and that's pressuring the market today," said Tim Ghriskey, chief investment officer of Solaris Group in Bedford Hills, New York.

The Intel results were offset somewhat by Morgan Stanley , which reported a fourth-quarter profit after a year-earlier loss, helped by higher revenue at the bank's institutional securities business. Its stock jumped 7.4 percent to $22.29.

Overall, S&P 500 fourth-quarter earnings rose an estimated 2.5 percent, according to Thomson Reuters data. Expectations for the quarter have dropped considerably since October, when a 9.9 percent gain was estimated.

The Dow Jones industrial average <.dji> was down 15.17 points, or 0.11 percent, at 13,580.85. The Standard & Poor's 500 Index <.spx> was down 3.51 points, or 0.24 percent, at 1,477.43. The Nasdaq Composite Index <.ixic> was down 13.98 points, or 0.45 percent, at 3,122.03.

On Thursday, the S&P 500 rose to its highest since late 2007, and that could prompt investors to lock in recent gains, analysts said.

Despite the day's decline, market sentiment was still positive on speculation that chances were better of avoiding a debt ceiling fight in Washington. House Republicans signaled on Thursday they might support a short-term extension of U.S. borrowing authority next month.

"The debt ceiling issue is sort of out of the news. The market has definitely become complacent. And we all know that the issue will be dealt with, we just need to find out when. If December is any guide, they are going to leave it up to the last minute so the market is definitely more complacent than it should be for now," Ghriskey said.

Reflecting the complacency, the CBOE Volatility index <.vix>, Wall Street's so-called fear gauge, fell 4.1 percent at just above 13. The VIX usually moves inversely to the S&P 500 as it is used as a hedge tool against further market decline.

Economic data from China provided some support to the market, though the focus remained on U.S. corporate earnings. The country's economy grew at a modestly faster-than-expected 7.9 percent in the fourth quarter, the latest sign the world's second-biggest economy was pulling out of a post-global financial crisis slowdown which saw it grow in 2012 at its weakest pace since 1999.

General Electric reported a better-than-expected rise in earnings, spurred by robust demand in China and oil-producing countries. Shares were up 2.9 percent to $21.92.

Despite the gains by Morgan Stanley, financial stocks sagged as Capital One Financial reported disappointing profit. Capital One slumped 7.7 percent to $56.87, while the KBW bank index <.bkx> slipped 0.9 percent.

Research In Motion climbed 6.6 percent to $15.91 after Jefferies Group boosted the BlackBerry maker's rating and price target.

(Editing by Bernadette Baum, Kenneth Barry and Nick Zieminski)

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As Rescue Operation Continues in Algeria, Fate of Hostages Remains Unclear

British Petroleum, via European Pressphoto Agency

The remote In Amenas natural gas field in Algeria, the site of a terrorist attack and the taking of hostages on Wednesday.

BAMAKO, Mali — Dozens of foreign hostages may still be held by Islamist extremists who have defied demands to surrender in a besieged Algerian gas-field complex, Algeria’s state-run news agency reported Friday, and the United States said for the first time that American citizens were among them.

Twelve Algerian and foreign workers have been killed since Algerian special forces began an assault against the kidnappers, the state news agency reported, citing an unnamed security official. It was the highest civilian death toll Algerian officials have provided in the aftermath of the assault, which freed captives and killed kidnappers but also left some hostages dead.

Previous estimates of the foreign casualties have ranged from 4 to 35.

The Algerian news agency said that the country’s special forces were still seeking to reach a “peaceful solution” with the remnants of a “terrorist group” that was still holding hostages in the refinery area of the gas field in remote eastern Algeria. It also gave a new sense of how many people may have been at the facility when the militants seized it on Wednesday, asserting that nearly 650 had managed to leave the site since then, including 573 Algerians and most of the 132 foreigners it said had been abducted.

But that still left many people unaccounted for, adding to the global concern about the fate of the hostages, who come from as many as 10 different nations.

.

In Washington, the State Department spokeswoman, Victoria Nuland, said that not all Americans had been freed and that Secretary of State Hillary Rodham Clinton had spoken for the third consecutive day by telephone with top Algerian leaders about American concerns for their safety.

“We have American hostages,” Ms. Nuland told reporters, offering the government’s first update on what is known about the Americans since officials confirmed on Thursday that seven or eight Americans had been inside the gas-field complex.

Ms. Nuland also said the United States would not consider a reported offer made by the kidnappers to exchange two Americans for two prominent figures imprisoned in the United States — Omar Abdel Rahman, a sheik convicted of plotting to bomb New York landmarks, and Aafia Siddiqui, a Pakistani woman convicted of shooting two American soldiers in Afghanistan. It was impossible to confirm that offer, which was reported by the Washington-based SITE Intelligence Group, a service that tracks jihadist activity on the Internet.

Intensifying the uncertainties, a spokesman for the militants, who belong to a group called Al Mulathameen, said Friday that they planned further attacks in Algeria, according to a report by the Mauritanian news agency ANI, which maintains frequent contact with militant groups in the region. The spokesman called upon Algerians to “keep away from the installations of foreign companies, because we will suddenly attack where no one would expect it,” ANI reported.

A Pentagon official said an Air Force C-130 had left Algeria for an unidentified base in Europe, carrying a number of the rescued hostages but no Americans. The official said a second, larger evacuation plane, a C-17, was still on the ground in Algeria, and it was unclear how many rescued hostages would be boarded or when it would depart.

A separate hostage situation of sorts appeared to be evolving at a village in Mali, the neighboring country where a French military intervention to stop radical Islamists may have been the catalyst for the Algerian gas-field seizure by the Al Mulathameen group.

A senior French official in Paris said Malian Islamist fighters, threatened by French and Malian soldiers, had occupied the village, Diabaly, and were threatening to use residents as human shields if attacked.

“We do not want a blood bath,” the French official said, and the troop commanders had chosen not to engage so far in house-to-house fighting.

The Algerian military operation at the gas field began on Thursday without consultation with the foreign governments whose citizens worked at the gas field facility. It has been marked by a fog of conflicting reports, compounded by the remoteness of the facility, near a town called In Amenas hundreds of miles across the desert from the Algerian capital, Algiers, and close to the Libyan border.

Algeria’s state radio, citing an official source, reported on Friday that 18 militants had been killed, the first precise death count offered by state media. The state news agency also suggested that hundreds of civilians “had been freed,” though many of the employees inside the sprawling facility may have simply been on site at the time of the militant assault and were not necessarily being held by the kidnappers.

Adam Nossiter reported from Bamako and Alan Cowell and Scott Sayare from Paris. Reporting was contributed by Rick Gladstone from New York; Elisabeth Bumiller, Julia Werdigier and John F. Burns from London; Steven Erlanger from Paris, Eric Schmitt, Thom Shanker, David E. Sanger and Michael R. Gordon from Washington; Martin Fackler and Hiroko Tabuchi from Tokyo; and Mayy El Sheikh from Cairo.

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With an air kiss or empty hug, Te’oing is Twitter craze

NEW YORK (Reuters) – Manti Te’o, the Notre Dame linebacker entangled in a girlfriend hoax that gives a whole new meaning to the term “air kiss,” is inspiring a new fad racing through social media: Te’oing.

An avalanche of pictures of people hugging empty chairs or puckering up to an otherwise empty room were posted to Twitter with the hashtag #Te’oing days after the college football star’s story about his girlfriend’s cancer death was exposed as a fraud. Not only did she never have leukemia, she never existed.

Notre Dame officials said Te’o told them he had been duped into believing he had an online relationship with the fictitious woman.

“Te’oing – Mile High Club edition” read one tweet with a photo of a man hugging the air in an airplane bathroom, an apparent reference to the whispered practice of having sex in mid-flight.

Clint Eastwood was hailed in several tweets as a “Te’oing” pioneer for the actor’s interlude with an empty chair at the 2012 Republican Convention. Other tweets showed Ronald McDonald Te’oing on his cozy bench and President Barack Obama spending quality time Te’oing with a vacant seat.

“Just some afternoon bubbly with my baby” said one Te’oing tweet with a photo of a man clinking his champagne flute against another that appeared to be suspended in mid-air.

The snarky social media frenzy recalled another similar trend called the “Tebowing,” named for New York Jets quarterback Tim Tebow, who frequently kneeled for on-field prayers and inspired copy-cat poses by people whose pictures flooded social media last year.

In its own riff on emptiness and romance, a Kentucky minor league baseball team, the Florence Freedom, has announced it will give away Manti Te’o Girlfriend Bobblehead dolls – actually empty boxes – to the first 1,000 fans at the May 23 game.

One section of the Florence, Kentucky, stadium has been reserved “for fans to sit with their imaginary friends, girlfriends/boyfriends or spouses” who may be caught on the “pretend kiss cam” and are invited to compete in an air guitar contest or an imaginary food fight.

(Writing by Barbara Goldberg; Editing by Paul Thomasch and Vicki Allen)

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Channing Tatum & Jenna Dewan-Tatum Share a Fresh, Healthy Lunch Date

Caught in the Act

01/18/2013 at 01:35 PM EST

Jenna Dewan-Tatum and Channing Tatum

FameFlynet

Eating for three?

Parents-to-be Jenna Dewan-Tatum and husband Channing, fresh from a beach holiday in St. Barts, enjoyed a casual lunch date together on Wednesday.

The couple, who wed in 2009 and announced their happy baby news in mid-December, shared their meal at Greenleaf Gourmet Chopshop in Beverly Hills.

Jenna, 32, went with healthy eating, dining on the restaurant's seasonal salad (kale, tangerine, dried blueberry, almonds and citrus vinagrette) while PEOPLE's Sexiest Man Alive, also 32 – and an Alabama native – chose more hearty Southern fare, specifically a barbecue chicken sandwich.

"They were a sweet couple and she's got a little bump too," said an onlooker.
– Jennifer Garcia

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