WHO: Slight cancer risk after Japan nuke accident


LONDON (AP) — Two years after Japan's nuclear plant disaster, an international team of experts said Thursday that residents of areas hit by the highest doses of radiation face an increased cancer risk so small it probably won't be detectable.


In fact, experts calculated that increase at about 1 extra percentage point added to a Japanese infant's lifetime cancer risk.


"The additional risk is quite small and will probably be hidden by the noise of other (cancer) risks like people's lifestyle choices and statistical fluctuations," said Richard Wakeford of the University of Manchester, one of the authors of the report. "It's more important not to start smoking than having been in Fukushima."


The report was issued by the World Health Organization, which asked scientists to study the health effects of the disaster in Fukushima, a rural farming region.


On March 11, 2011, an earthquake and tsunami knocked out the Fukushima plant's power and cooling systems, causing meltdowns in three reactors and spewing radiation into the surrounding air, soil and water. The most exposed populations were directly under the plumes of radiation in the most affected communities in Fukushima, which is about 150 miles (240 kilometers) north of Tokyo.


In the report, the highest increases in risk are for people exposed as babies to radiation in the most heavily affected areas. Normally in Japan, the lifetime risk of developing cancer of an organ is about 41 percent for men and 29 percent for women. The new report said that for infants in the most heavily exposed areas, the radiation from Fukushima would add about 1 percentage point to those numbers.


Experts had been particularly worried about a spike in thyroid cancer, since radioactive iodine released in nuclear accidents is absorbed by the thyroid, especially in children. After the Chernobyl disaster, about 6,000 children exposed to radiation later developed thyroid cancer because many drank contaminated milk after the accident.


In Japan, dairy radiation levels were closely monitored, but children are not big milk drinkers there.


The WHO report estimated that women exposed as infants to the most radiation after the Fukushima accident would have a 70 percent higher chance of getting thyroid cancer in their lifetimes. But thyroid cancer is extremely rare and one of the most treatable cancers when caught early. A woman's normal lifetime risk of developing it is about 0.75 percent. That number would rise by 0.5 under the calculated increase for women who got the highest radiation doses as infants.


Wakeford said the increase may be so small it will probably not be observable.


For people beyond the most directly affected areas of Fukushima, Wakeford said the projected cancer risk from the radiation dropped dramatically. "The risks to everyone else were just infinitesimal."


David Brenner of Columbia University in New York, an expert on radiation-induced cancers, said that although the risk to individuals is tiny outside the most contaminated areas, some cancers might still result, at least in theory. But they'd be too rare to be detectable in overall cancer rates, he said.


Brenner said the numerical risk estimates in the WHO report were not surprising. He also said they should be considered imprecise because of the difficulty in determining risk from low doses of radiation. He was not connected with the WHO report.


Some experts said it was surprising that any increase in cancer was even predicted.


"On the basis of the radiation doses people have received, there is no reason to think there would be an increase in cancer in the next 50 years," said Wade Allison, an emeritus professor of physics at Oxford University, who also had no role in developing the new report. "The very small increase in cancers means that it's even less than the risk of crossing the road," he said.


WHO acknowledged in its report that it relied on some assumptions that may have resulted in an overestimate of the radiation dose in the general population.


Gerry Thomas, a professor of molecular pathology at Imperial College London, accused the United Nations health agency of hyping the cancer risk.


"It's understandable that WHO wants to err on the side of caution, but telling the Japanese about a barely significant personal risk may not be helpful," she said.


Thomas said the WHO report used inflated estimates of radiation doses and didn't properly take into account Japan's quick evacuation of people from Fukushima.


"This will fuel fears in Japan that could be more dangerous than the physical effects of radiation," she said, noting that people living under stress have higher rates of heart problems, suicide and mental illness.


In Japan, Norio Kanno, the chief of Iitate village, in one of the regions hardest hit by the disaster, harshly criticized the WHO report on Japanese public television channel NHK, describing it as "totally hypothetical."


Many people who remain in Fukushima still fear long-term health risks from the radiation, and some refuse to let their children play outside or eat locally grown food.


Some restrictions have been lifted on a 12-mile (20-kilometer) zone around the nuclear plant. But large sections of land in the area remain off-limits. Many residents aren't expected to be able to return to their homes for years.


Kanno accused the report's authors of exaggerating the cancer risk and stoking fear among residents.


"I'm enraged," he said.


___


Mari Yamaguchi in Tokyo and AP Science Writer Malcolm Ritter in New York contributed to this report.


__


Online:


WHO report: http://bit.ly/YDCXcb


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Wall Street edges up as data outweighs sequester

NEW YORK (Reuters) - Stocks rose modestly on Friday as strong economic data outweighed growth concerns in China and Europe and let investors brush off worries about the impact of expected across-the-board government spending cuts.


Stocks opened sharply lower as Asian factories slowed and European output fell, but most of the losses dissipated after a report showed U.S. manufacturing activity expanded last month at its fastest clip in 20 months and put the S&P 500 index on track for a slight weekly gain.


U.S. consumer confidence also rose in February as Americans turned more optimistic about the job market.


With government budget cuts set to begin on Friday, President Barack Obama blamed Republicans for failure to reach a compromise to avert the cuts, known as sequester. But the stock market appeared to have already priced in the failure by legislators to reach an agreement.


"The positive manufacturing data, better than expected, sends a signal the economy itself, and manufacturing in particular, is showing signs of strength - trumping any concern that people seem to have with the sequester cuts," said Terry Sandven, chief equity strategist at U.S. Bank Wealth Management in Minneapolis.


The Dow Jones industrial average <.dji> gained 40.43 points, or 0.29 percent, to 14,094.92. The Standard & Poor's 500 Index <.spx> added 4.01 points, or 0.26 percent, to 1,518.69. The Nasdaq Composite Index <.ixic> rose 9.56 points, or 0.30 percent, to 3,169.75.


For the week so far, the Dow is up 0.7 percent, the S&P 500 is up 0.2 percent and the Nasdaq is up 0.3 percent.


The low interest rates due to the Federal Reserve's accommodative monetary policy have helped equities continue to attract investors. The Dow is less than 1 percent away from its all-time intraday high of 14,198.10. Declines have been shallow and short-lived, with investors jumping in to buy on dips.


Intuitive Surgical jumped 8.7 percent to $554.43 after Cantor Fitzgerald analyst Jeremy Feffer upgraded the stock, saying the stock's more than 11 percent slide on Thursday was a gross overreaction to a news report.


Groupon Inc surged 12.2 percent to $5.08 a day after the online coupon company fired its chief executive officer in the wake of weak quarterly results.


Gap Inc rose 3 percent to $33.87 after reporting fourth-quarter earnings that beat expectations and boosting its dividend by 20 percent, while Salesforce.com Inc posted sales that beat forecasts, driving its stock up 7.1 percent to $181.28.


Chesapeake Energy Corp fell 2.2 percent to $19.71 after the U.S. Securities and Exchange Commission escalated its investigation into the company and its Chief Executive Aubrey McClendon for a controversial perk that granted him a share in each of the natural gas producer's wells.


(Additional reporting by Rodrigo Campos; Editing by Jan Paschal)



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India Ink: Image of the Day: March 1

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Bonnie Franklin Dies at 69






Breaking News








UPDATED
03/01/2013 at 02:20 PM EST

Originally published 03/01/2013 at 01:35 PM EST



One Day at a Time star Bonnie Franklin, who announced last September that she was suffering from pancreatic cancer, died of complications of the disease on Friday, her family told the Los Angeles Times. She was 69.

Franklin died at her Los Angeles home, and is survived by her mother, Claire Franklin, and stepchildren Jed Minoff and Julie Minoff, said the paper.

On the long-running CBS series, which was developed by Norman Lear and on the air from 1975-1984, Franklin starred as divorced mom Ann Romano, alongside Mackenzie Phillips and Valerie Bertinelli, who played her teenage daughters.

Franklin and Bertinelli reunited on the small screen in 2011 when the Franklin played the mother of Bertinelli's character's boyfriend on Hot in Cleveland.

When Franklin's disease was first revealed, Phillips Tweeted, "Sending out love and sweet prayers to my 'mom.' The incomparable Bonnie Franklin."

A California native, Franklin was born in the beach city of Santa Monica but moved to Beverly Hills as a teen. Her father was a Russian-born investment banker, and her mother was born in Romania – and they remained her most ardent fans. She attended Smith College in Massachusetts and then transferred to UCLA.

Acting since childhood, Franklin first appeared on TV at the age of 3 (reciting Shakespeare) and in movies – including Alfred Hitchcock's The Wrong Man, starring Henry Fonda. In 1970 she sang the title song in the Tony-winning Lauren Bacall Broadway musical Applause. Franklin played a sunny chorus gypsy, and stopped the show twice.

From 1967 to 1970 she was married to the playwright Ronald Sossi, and then from 1980 until his death in 2009, to producer Marvin Minoff. Speaking to The New York Times about their marriage in 1980, Franklin said that she had promised Minoff that their years together would be many things, "but I promised him they weren't going to be boring."

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WHO: Small cancer risk after Fukushima accident


LONDON (AP) — People exposed to the highest doses of radiation during Japan's Fukushima nuclear plant disaster in 2011 may have a slightly higher risk of cancer but one so small it probably won't be detectable, the World Health Organization said in a report released Thursday.


A group of experts convened by the agency assessed the risk of various cancers based on estimates of how much radiation people at the epicenter of the nuclear disaster received, namely those directly under the plumes of radiation in the most affected communities in Fukushima, a rural agricultural area about 150 miles (240 kilometers) north of Tokyo.


Some 110,000 people living around the Fukushima Dai-ichi nuclear plant were evacuated after the massive earthquake and tsunami on March 11, 2011 knocked out the plant's power and cooling systems, causing meltdowns in three reactors and spewing radiation into the surrounding air, soil and water.


In the new report, the highest increases in risk appeared for people exposed as infants to radiation in the most heavily affected areas. Normally in Japan, the lifetime risk of developing cancer of an organ is about 41 percent for men and 29 percent for women. The new report said that for infants in the most heavily exposed areas, the radiation from Fukushima would add about 1 percentage point to those numbers.


"These are pretty small proportional increases," said Richard Wakeford of the University of Manchester, one of the authors of the report.


"The additional risk is quite small and will probably be hidden by the noise of other (cancer) risks like people's lifestyle choices and statistical fluctuations," he said. "It's more important not to start smoking than having been in Fukushima."


Experts had been particularly worried about a spike in thyroid cancer, since iodine released in nuclear accidents is absorbed by the thyroid, especially in children. After the Chernobyl disaster, about 6,000 children exposed to radiation later developed thyroid cancer because many drank contaminated milk after the accident.


In Japan, dairy radiation levels were closely monitored, but children are not big milk drinkers there.


WHO estimated that women exposed as infants to the most radiation after the Fukushima accident would have a 70 percent higher chance of getting thyroid cancer in their lifetimes. But thyroid cancer is extremely rare, one of the most treatable cancers when caught early, and the normal lifetime risk of developing it is about 0.75 percent. That risk would be half of one percentage point higher for women who got the highest radiation doses as infants.


Wakeford said the increase in such cancers may be so small it will probably not be observable.


For people beyond the most directly affected areas of Fukushima, Wakeford said the projected risk from the radiation dropped dramatically. "The risks to everyone else were just infinitesimal."


David Brenner of Columbia University in New York, an expert on radiation-induced cancers, said that although the risk to individuals is tiny outside the most heavily exposed areas, some cancers might still result, at least in theory. But they'd be too rare to be detectable in overall cancer rates, he said.


Brenner said the numerical risk estimates in the WHO report were not surprising. He also said they should be considered imprecise because of the difficulty in determining risk from low doses of radiation. He was not connected to the WHO report.


Some experts said it was surprising that any increase in cancer was even predicted.


"On the basis of the radiation doses people have received, there is no reason to think there would be an increase in cancer in the next 50 years," said Wade Allison, an emeritus professor of physics at Oxford University, who was not connected to the WHO report. "The very small increase in cancers means that it's even less than the risk of crossing the road," he said.


WHO acknowledged in its report that it relied on some assumptions that may have resulted in an overestimate of the radiation dose in the general population.


Gerry Thomas, a professor of molecular pathology at Imperial College London, accused the WHO of hyping the cancer risk.


"It's understandable that WHO wants to err on the side of caution, but telling the Japanese about a barely significant personal risk may not be helpful," she said.


Thomas said the WHO report used inflated estimates of radiation doses and didn't properly take into account Japan's quick evacuation of people from Fukushima.


"This will fuel fears in Japan that could be more dangerous than the physical effects of radiation," she said, noting that people living under stress have higher rates of heart problems, suicide and mental illness.


In Japan, Norio Kanno, the chief of Iitate village, in one of the regions hardest hit by the disaster, harshly criticized the WHO report on Japanese public television channel NHK, describing it as "totally hypothetical."


Many people who remain in Fukushima still fear long-term health risks from the radiation, and some refuse to let their children play outside or eat locally-grown food. Kanno accused the report of exaggerating the cancer risk and stoking fear among residents.


"I'm enraged," he said.


___


Mari Yamaguchi in Tokyo and AP Science Writer Malcolm Ritter in New York contributed to this report.


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Croatia Withdrawing Soldiers from U.N. Force on Israel-Syria Frontier





Prime Minister Zoran Milanovic of Croatia said Thursday that his country would withdraw its soldiers from a United Nations peacekeeping force in the Golan Heights following reports that Croatia was funneling weapons to antigovernment fighters in Syria.




Croatia has nearly 100 soldiers serving with the United Nations Disengagement Observer Force, which is responsible for maintaining the fragile calm between Israeli and Syrian troops at the demilitarized zone along Syria’s Golan frontier that was established after a cease-fire ended the 1973 war.


The decision to withdraw the soldiers from the area came after The New York Times reported on Monday that Saudi Arabia had underwritten a large purchase of infantry arms in Croatia. Croatia has denied selling weapons to either Saudi Arabia or the Syrian rebels. But Mr. Milanovic said that reports of the sales had put Croatian soldiers at risk and that he was compelled to withdraw them because their safety could no longer be assured.


“We can deny over and over again, but everyone has already read these reports and our soldiers are no longer safe. We want them to return home safe and sound,” he told a cabinet meeting in Zagreb, the capital of Croatia. Citing the Times report, he said, “We can’t be sure if someone will take action against our units after the release of the information.”


According to United States and Western officials, in December arms left over from the Balkan wars of the 1990s began to reach rebels battling the forces of President Bashar al-Assad of Syria, via Jordan.


Since then, officials said, several planeloads of weapons had left Croatia. Yugoslav weapons previously unseen in the conflict, including recoilless guns, assault rifles and machine guns, began to appear in videos posted by Syrian rebels on YouTube.


The infusion of arms appeared to signify a more activist approach to helping Syria’s armed opposition, and as a counterweight to Iranian support for the Assad government.


Before the Arab Spring uprisings of 2011, Croatia had relatively strong political and economic ties to Damascus. But analysts said that Croatia, which is to join the European Union this year, had since firmly sided with the rebels, abiding by European Union sanctions against Damascus, offering financial aid to Syrian refugees and recognizing the Syrian opposition as the only legitimate representative of the Syrian people.


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HP sells webOS operating system to LG Electronics






SAN FRANCISCO (Reuters) – Hewlett-Packard Co said on Monday it will sell the webOS operating system to South Korea’s LG Electronics Inc, unloading the smartphone software it acquired through a $ 1.2 billion acquisition of Palm in 2010.


LG will use the operating software, used in now-defunct Palm smartphones years ago, for its “smart” or Internet-connected TVs. The Asian electronics company had worked with HP on WebOS before offering to buy it outright.






Under the terms of their agreement, LG acquires the operating software’s source code, associated documentation, engineering talent, various associated websites, and licenses under HP’s intellectual property including patents covering fundamental operating system and user interface technology.


HP will retain the patents and all the technology relating to the cloud service of webOS, HP Chief Operating Officer Bill Veghte said in an interview.


“As we looked at it, we saw a very compelling IP that was very unique in the marketplace,” he said, adding that HP has already had a partnership with LG on webOS before the deal was announced.


“As a result of this collaboration, LG offered to acquire the webOS operating system technology,” Veghte said.


Skott Ahn, President and CTO, LG Electronics, said the company will incorporate the operating system in the Smart TV line-up first “and then hopefully all the other devices in the future.”


Both companies declined to reveal the terms of the deal.


LG will keep the WebOS team in Silicon Valley and, for now, will continue to be based out of HP offices, Ahn said.


HP opened its webOS mobile operating system to developers and companies in 2012 after trying to figure out how to recoup its investment in Palm, one of the pioneers of the smartphone industry.


The company had tried to build products based on webOS with the now-defunct TouchPad tablet its flagship product.


HP launched and discontinued the TouchPad in 2010, a little over a month after it hit store shelves with costly fanfare after it saw poor demand for a tablet priced on par with Apple’s dominant iPad.


WebOS is widely viewed as a strong mobile platform, but has been assailed for its paucity of applications, an important consideration while choosing a mobile device.


(Additional reporting By Paul Sandle and Alistair Barr; Editing by Gerald E. McCormick, Tim Dobbyn and M.D. Golan)


Tech News Headlines – Yahoo! News





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Natalie and Derrica Wilson Help Find the Missing






Heroes Among Us










02/28/2013 at 02:45 PM EST







Natalie Wilson (left) and Derrica Wilson


Shaul Schwarz


One spring day in 2004 a young African-American woman named Tamika Huston vanished from her Spartanburg, S.C., apartment.

Her family did everything they could to get the media to pay attention to the 24-year-old's disappearance, sending out emails, calling newspapers and TV stations – to no avail.

"It was painful watching them struggle for any kind of media coverage-local or national," says Derrica Wilson, who was born and raised in Spartanburg. "This could have been one of my family members."

One year almost to the day later, high school senior Natalee Holloway disappeared in Aruba. And that story, of course, was everywhere. "It made me angry but angry in a positive way," says Derrica. "I wanted to do something to help families like Tamika's."

So she turned to her own family to make that happen. In 2008, Derrica and her sister-in-law, Natalie Wilson, started the Black and Missing Foundation, a non-profit geared toward helping minority families find missing loved ones. By working closely with police, the media and the families themselves, they have helped locate more than 113 missing people – 71 of them alive.

It's a daunting task: Thousands of African-Americans go missing each year (one-third of all missing-persons cases). The problem has caught Hollywood's eye: Tyler Perry recently offered a $100,000 reward for tips leading to the discovery of two missing Florida men.

The Wilsons fund the foundation out of their own pockets and make themselves available day and night to grieving families – even though they both have full-time jobs and families of their own. "Let's just say it's a calling," says Derrica, 34. They have more than 2,000 cases in their database (they only take on cases in which police reports were filed).

"I believe in what they do," says Washington, D.C. assistant police chief Diane Groomes, who was so impressed with their work she joined their board of directors.

The sisters in law divvy up their duties based on what they do best. Derrica, a cop for years who currently works as an investigator for a D.C. agency, coaches families on how to deal with law enforcement and the media. Natalie, 43, a public relations expert, works on getting the cases coverage on radio, newspapers, the web and television.

They've also partnered with TV One and national radio host Michael Baisden to get ongoing coverage of different cases. "It's one of the most fulfilling experiences I've ever had," says Baisden, whose show has helped find 14 children. "There is nothing more traumatizing than losing your child and not knowing if they are alive or dead."

On Feb. 13, the sisters-in-law started a support group for families that meets weekly in Washington, D.C. "Coping with a missing loved one is traumatic and overwhelming," says Natalie. "We want families to know that they are not alone." On May 25, they will host a 5K run in Ft. Washington, Md. to raise awareness of the issue.

No one is more appreciative of these efforts than the families they are helping. "If I had the next hundred years I couldn't thank them enough," says Unique Harris, 45, who says Derrica and Natalie got the Washington, D.C. media to give some much-needed attention to the still-unsolved disappearance of her daughter Valencia, 24.

"When I talk to Natalie and Derrica I let them know I love them, "she says, "and they're like family now."

Know a hero? Send suggestions to heroesamongus@peoplemag.com. For more inspiring stories, read the latest issue of PEOPLE magazine

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Vt. lye victim gets new face at Boston hospital


BOSTON (AP) — The 2007 chemical attack left the Vermont nurse unrecognizable to anyone who knew her.


But now Carmen Blandin Tarleton's face has changed again following a facial transplant this month.


Doctors at Brigham & Women's Hospital in Boston said Wednesday that the 44-year-old's surgery included transplanting a female donor's facial skin to Tarleton's neck, nose and lips, along with facial muscles, arteries and nerves.


"I know how truly blessed I am, and will have such a nice reflection in the mirror to remind myself what selfless really is," Tarleton wrote on her blog Wednesday.


The Thetford, Vt., woman suffered burns on more than 80 percent of her body and was blinded after her estranged husband attacked her with a baseball bat and doused her with lye in 2007.


Tarleton, who once worked as a transplant nurse, has undergone more than 50 surgeries since the attack, including work to restore some of her vision.


The latest surgery took 15 hours and included a team of more than 30 medical professionals. The lead surgeon, Bohdan Pomahac, called her injuries among the worst he's seen in his career.


"Carmen is a fighter," the doctor said Wednesday. "And fight she did."


Pomahac's team has performed five facial transplants at the hospital. He said the patient is recovering very well and is in great spirits as she works to get stronger.


He said she was very pleased when she saw her face for the first time, and that her appearance will not match that of the late donor's face.


"I think she looks amazing, but I'm biased," he said with a smile.


The donor's family wants to remain anonymous, but released a statement through a regional donor bank saying that her spirit would live on through Tarleton and three other organ recipients.


The estranged husband, Herbert Rodgers, pleaded guilty in 2009 in exchange for a prison sentence of at least 30 years.


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IHT Rendezvous: Eve Best Returns to the Globe, This Time as a Director

LONDON — The recent press conference announcing the 2013 season at Shakespeare’s Globe on one level seemed like variations on an ongoing theme.

A onetime Falstaff at this address, Roger Allam, is returning to open the season as Prospero in “The Tempest,” directed by Jeremy Herrin, while the perennial favorite, “A Midsummer Night’s Dream,” will be seen in May in a new staging, this time from the Globe’s artistic director, Dominic Dromgoole. The 2011 Olivier winner Michelle Terry (“Tribes”) will play Titania.

The international season that so galvanized the space for six weeks last spring will return in a greatly pared-down form, and there will be three new plays, including one, “Blue Stockings” by Jessica Swale, that tells of the first female students at Cambridge University.

But it’s the last in the trio of supernaturally charged Shakespeares that promises to break fresh theatrical ground. In what represents her first-ever stab (you’ll forgive the word in context) at directing, the much-laureled actress Eve Best will stage a new production in June of “Macbeth.” Joseph Millson and Samantha Spiro have signed on as the murderous couple at the play’s black, bleak heart.

What prompted one of the most accomplished stage performers of her generation (an actress with an Olivier Award and two Tony nominations) to make the shift? The answer was arrived at via a lengthy phone call to a remote island in Denmark, where Ms. Best, 41, is currently filming “Someone You Love” for the director Lars von Trier’s Zentropa production group. This film’s specific director is Pernille Fischer Christensen.

To hear Ms. Best describe it, she thought her time at the Globe was finished, at least for a while, following a triumphant 2011 production of “Much Ado About Nothing” in which she played Beatrice opposite Charles Edwards’s no less witty and scintillating Benedick. (That staging opened within days of a contrasting commercial production of the same play, with David Tennant and Catherine Tate, and trumped its starrier competitor hands down.)

“I love the Globe so much,” Ms. Best recalled, “and wanted any excuse to spend some time there, having played Beatrice which was just my most favorite part ever. But I did think I was sort of running out of parts to play for a little while until I get into the world of Cleopatra and those kinds of parts” — that’s to say, Shakespeare’s more senior women.

But all that was before Mr. Dromgoole surprised Ms. Best with an offer to take on the directing of the Shakespeare tragedy in which she had made her Globe debut in 2001, opposite Jasper Britton.

“I put myself forward to direct something thinking that they might say yes in a couple of years and that if they did say yes they might start me off with something light or something simpler or more obscure,” she said.

“I was not prepared for them to turn around and say, ‘Yes, all right, and what about “Macbeth?”’ Ms. Best continued, delight evident in her voice. “It took me back. My first response was: ‘Absolutely no way; you must be kidding!’”

The play is particularly challenging at the Globe. Open to the elements, the theater is a tricky fit for a text suffused with darkness, and it can be hard to focus the gathering intensity of the Macbeths’ toxic rise and fall.

“We are in the broad daylight and the open air,” Ms. Best acknowledged, “and that particular circular shape is certainly going to have a significant effect on the kind of production ours is. We can’t set it in the dark with candles, so we just have to embrace what it is that the Globe will give us: I’m very interested in just seeing the play as clearly as we possibly can and focusing on the human relationships within it.”

Mr. Dromgoole for his part said he thought Ms. Best would be able to meet the play head-on without lots of additional mumbo jumbo. “I wanted someone who I thought could just let [“Macbeth”] play itself rather than forcing it down a tunnel of darkness.”

As it happens, Ms. Best has firsthand knowledge of both central roles. In addition to acting Lady Macbeth at the Globe, she participated in workshops of the play in New York with the Scottish actor Alan Cumming in which she played the title role opposite Mr. Cumming’s Lady. Mr. Cumming is soon to open his own solo take on the play on Broadway.

(For those collecting “Macbeths,” the West End is now hosting the film actor James McAvoy in a modern-dress, gory, commendably visceral version. That one, at the Trafalgar Studios, will have finished roughly two months before Ms. Best’s begins.)

“What’s really lovely about this play — and all Shakespeare plays obviously — is that they are so magnificently and eminently flexible,” said Ms. Best, who was sounding in no way deterred by other productions arriving before hers. “They can encompass 6 or 8 or 10 productions all going on at the same time, all equally fascinating, all equally interesting, with all kinds of different approaches.”

Nor was she sounding spooked by a famously hexed play that has on occasion brought disaster in its wake. Whereas theater lore, for instance, often insists that those involved with this text refer to it as “the Scottish play,” Ms. Best was having none of that.

“I’ve been saying it like mad,” she said. “If we’re going to be working on it for two months, life’s too short to be worried.”

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